RIPK3 and acute kidney injury: Necroptosis is associated with renal ischemia–reperfusion injury and cisplatin-induced AKI [11, 12], and knocking out the RIP3 gene or RIP3 inhibitor can protect mice with renal ischemia–reperfusion injury from severe AKI [11]; thus, necroptosis may be a new therapeutic target for AKI.