On the other hand, a salt intake lower than 5.8 g/d was reported to be associated with the activation of the renin–angiotensin–aldosterone system, increased plasma lipids, and increased mortality [51]; risk of myocardial infarction, cardiovascular diseases, and all-cause mortality was increased among hypertensive patients with increased plasma renin activity and low-urinary levels of Na [53, 54]. Here, REN is linked to cardiovascular disorder.