LGALS9 and neoplasm: In another research, to enhance immunotherapy and reprogram tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC), Zhou et al. constructed an exosome-based delivery system (iEXO-OXA) that loaded with galectin-9 siRNA and surficially modified with oxaliplatin (OXA) to reverse immunosuppression and trigger ICD.