In this study, we found a marked increase in the AMPA receptor subunits GluA1 and GluA2 in the hippocampus after (2R,6R)-HNK administration in CRS mice, whereas pretreatment with NBQX significantly blocked the effects of (2R,6R)-HNK, which is consistent with the recent finding that (2R,6R)-HNK administration induces the upregulation of synaptic AMPA receptors [13, 29]. Here, GRIA1 is linked to congenital rubella syndrome.