AFP and neoplasm: Physical examination, especially DRE, complete blood count, blood biochemical examination (aspartate aminotransferase, alanine aminotransferase, creatinine, blood urea nitrogen), thyroid hormone, adrenal hormone, myocardial enzymogram, and serum tumour marker (CEA, CA199, AFP, CA724, CA242, CA50, etc.)analyses, and imaging examinations (pelvic MRI, abdominopelvic CT and chest CT) will be performed every 3 months.