Figure 5b showed that serum exosomal ITGAM was higher expressed in the advanced lung adenocarcinoma group compared with the healthy control group (p < 0.001), and CLU was higher expressed in the advanced lung adenocarcinoma group compared with the early lung adenocarcinoma group (p < 0.001) and the healthy control group (p < 0.001). This evidence concerns the gene CLU and lung adenocarcinoma.