Autophagic flow is reduced when lung tissue exhibits fibrotic lesions in bleomycin (BLM) and TGF-β-induced IPF mouse models, as well as in a TGF-β-mediated fibroblast-to-myofibroblast differentiation (FMD) in vitro model [19]. This evidence concerns the gene TGFB1 and idiopathic pulmonary fibrosis.