Further, the inhibition of the Notch-1 or TLR4 signalling pathway decreased TNF-α levels in DRG neurons from diabetic neuropathic rats; therefore, it can be said that inhibition of either the Notch-1 signalling pathway or the TLR4 signalling pathway may improve mechanical allodynia and thermal hyperalgesia thresholds in diabetic neuropathy [206]. This evidence concerns the gene TLR4 and diabetic neuropathy.