CHRNA7 and Alzheimer disease: Further, studies have highlighted the neuroprotective effects of NSAIDs, which target α7-nAChRs, the inhibitor of acetylcholinesterase and peroxisome proliferator-activated receptors (PPARs), primarily by activating the Wnt signalling pathway and thereby, conferring protection against Aβ-induced toxicity in AD brains [283].