In the SMART MR study (patients with midlife hypertension and manifest atherosclerotic disease) patients prescribed angiotensin receptor blockers did not show a decline CBF over a period of 3.9 years, whereas CBF declined in patients taking other classes of antihypertensive medications (calcium channel blockers, angiotensin-converting enzyme inhibitors, diuretics, and beta-blockers).23 This evidence concerns the gene ACE and Hypertension.