In the present study, we have tested whether inhibition of the Tp53-Induced Glycolysis and Apoptosis Regulator (TIGAR) using a targeted small-interfering RNA (siRNA-tigar) could sensitize the HPV18-transformed HeLa cervical adenocarcinoma cell-line to genotoxic chemotherapy agents that induce oxidative stress and DNA-damage in efforts to determine whether TIGAR-mediated antioxidant signaling promotes therapy-resistance in hrHPV-associated cancers [19–24]. This evidence concerns the gene TIGAR and cervical adenocarcinoma.