According to their results, articaine did not increase the methemoglobin level whenadministered for dental anesthesia, but methemoglobinemia can occur following intravenous regional anesthesia by articaine.Reports regarding methemoglobinemia following administration of lidocaine in dental procedures, transesophageal echocardiography, endoscopy,and endobronchial intubation are noticeable in the literature, but there is a general agreement regarding the clinically tolerable methemoglobin levels following lidocaine administration [ 2, 5, 14 ]. This evidence concerns the gene HBG2 and methemoglobinemia.