SDC1 and ulcer disease: It may be caused by the inflamed periodontium of the periodontal pocket and its consequent pathological changes [ 9], such as transformation of the junctional epithelium to the stratified squamous epithelium, the emergence of the characteristics of continuous epithelial rapid increase,movement, creation of rete ridge, ulcers, the presence of integrin 6 4 and syndecan-1 (potential receptors of HPV) [ 16].