To clarify SSRP1's function in GC and its mechanism of action, therefore, SSRP1 expression in GC cells and tissues was explored through a series of functional assays, and its effects on the proliferative capacity, apoptosis, invasion and migration of GC cells via the protein kinase B (AKT) pathway were determined, thereby providing new ideas for the targeted clinical treatment of GC. This evidence concerns the gene AKT1 and gastric cancer.