One study (Liu et al., 2015) detected the expression of IER3 in 62 cases of HCC tumors by IHC and found that IER3 expression was significantly correlated with the expression of P53 and Ki-67, and the maximum diameter and degree of differentiation of the tumor were related to the upregulated expression of IER3. Here, TP53 is linked to hepatocellular carcinoma.