VOI-based analysis of susceptibility values reflected the most marked findings ofthe finer-grained VBA presented previously: susceptibility values weresignificantly higher in SCA1 and MSA-C patients than in the correspondingcontrols when DNbulk was considered (Fig. 4B), whereas susceptibility values weresignificantly lower in SCA6 patients compared with controls whenDNsil was considered (Fig.4A). Here, CACNA1A is linked to multiple system atrophy, cerebellar type.