ACE2 and Hyperglycemia: Several factors such as hyperglycemia, changes in cytokine production, impaired T cell-mediated immune response, inhibition of neutrophil chemotaxis, ineffective microbial clearance, and phagocytic cell dysfunction may exacerbate immune dysfunction in diabetics.14 ACE2 may play a vital role in the severity of COVID-19 infection in diabetics because it is expressed in pancreatic tissue, and the virus uses this enzyme to attack host pneumocytes.