MAPT and tauopathy: In fact, increasing evidence has shown that Tau pathology may play a more significant role than Aβ protein deposition, as some studies found only minor effects caused by Aβ on cognition in normal older adults (Baker et al., 2017; Bloom, 2017; Duke Han et al., 2018), and that Aβ deposition has to be accompanied with tauopathy in order to have considerable impact on cognition (Desikan et al., 2016; Jansen et al., 2019; Soldan et al., 2012; Soldan et al., 2018).