ADIPOQ and obesity due to melanocortin 4 receptor deficiency: Our study supports the obesity paradox (Frisardi et al., 2020), but this theory has been highly controversial as the negative effects of obesity are obvious, for example, insulin resistance (Kleinridders et al., 2017; Waki et al., 2014), oxidative stress (Rodriguez‐Casado et al., 2013), lepin (Burguera et al., 2009; Gorrini et al., 2000), and adiponectin (Lieb, 2016).