As was reported by us and others, another tyrosine receptor kinases pathway which depends on the WWOX expression gene is ERBB4 signaling in breast cancer cells (Bednarek et al. 2000, 2001; Nunez et al. 2005; Aqeilan et al. 2005; Iliopoulos et al. 2007). This evidence concerns the gene ERBB4 and breast cancer.