Intriguingly, during the preparation of our manuscript, the Lou group reported that the MAP4K4/5/6 kinases, which are the functional paralogs of MST1/2 in the Hippo pathway and STRIPAK complexes, can limit DSB repair capacity and mediate cancer cell sensitivity to genotoxic agents at low extracellular stiffness conditions (51). The gene discussed is MAP4K4; the disease is cancer.