Seo et al. have reported that the therapeutic efficacy of drugs varies in patients of epilepsy with different ABCB1 C3435T genotypes and there is no statistical difference in the plasma concentration dose ratio (C/D) of CBZ in the plasma of different genotype groups, suggesting that patients in the drug-resistant genotype group may develop drug resistance by restricting AEDs to pass through the blood-brain barrier to reach brain cells [119]. Here, ABCB1 is linked to epilepsy.