To identify the specific mechanism of SFRP4 in diabetic cardiomyopathy, the analysis of the MINT database (https://mint.bio.uniroma2.it/) and the BioGRID database (https://thebiogrid.org/) revealed its ability to bind to protein tyrosine phosphatase nonreceptor type 12 (PTPN12). The gene discussed is PTPN12; the disease is diabetic cardiomyopathy.