CIZ1 and medulloblastoma: The first CIZ1 variant implicated in human disease, the pediatric central nervous system tumor medulloblastoma, lacks PLD1 (Warder and Keherly, 2003); more recently, exome sequencing has revealed polymorphisms in the length of the polyQ tract in PLD1, with deletion of nine glutamines reported in seven malignant tumors of different origins.