The first CIZ1 variant implicated in human disease, the pediatric central nervous system tumor medulloblastoma, lacks PLD1 (Warder and Keherly, 2003); more recently, exome sequencing has revealed polymorphisms in the length of the polyQ tract in PLD1, with deletion of nine glutamines reported in seven malignant tumors of different origins. Here, CIZ1 is linked to cancer.