Alterations that impact PLD1, or that occur elsewhere and influence alternative splicing and tendency to aggregate inside cells, are also linked with familial cervical dystonia (Xiao et al., 2012; Xiao et al., 2014) and Alzheimer’s disease (Dahmcke et al., 2008), and other mutations with benign essential blepharospasm (Dong et al., 2019). Here, PLD1 is linked to Alzheimer disease.