Since base damage (e.g. oxidative, alkylation, uracil, and so on) caused by endogenous and exogenous damaging sources is prevalently associated with cancer mutations (Tubbs and Nussenzweig, 2017; Wallace et al., 2012), a potential mechanism for mutation elevation in non-UV exposed tumors is increased base damage formation and/or suppressed BER in TF-bound DNA. This evidence concerns the gene TF and cancer.