DDIT3 and Hyperglycemia: To clarify whether hyperglycemia-triggered ATF6-CHOP influenced β-catenin signaling during liver IRI, we examined the signaling in ischemic liver tissues from WT and CHOP−/− hyperglycemic mice after 6 h reperfusion and revealed that CHOP deficiency effectively restored hyperglycemia-inhibited β-catenin expression in control hyperglycemic mice (Fig. 5B and Supporting Fig. S2B).