In addition, male sex, age >60 years, III and IV pathological stage, pleural invasion, smoking status, necrosis, STAS, vascular invasion, positive PD-L1 expression, Ki67 ≥ 15%, lymphatic metastasis, morphology with solid and micropapillary components, squamous carcinoma and other pathological types were significantly associated with shorter OS and PFS. This evidence concerns the gene CD274 and squamous cell carcinoma.