We found that alternative splicing of NEMO was also highly correlated to the “3-genes NF-κB/STAT1score” that distinguishes patients with NDAS from those with other type I interferonopathies, such as chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) and stimulator of IFN genes–associated (STING-associated) vasculopathy with onset in infancy (SAVI), and consistent with our NF-κB correlation, the “11-gene NF-κB-only validation score” was also highly correlated with alternative NEMO splicing (Supplemental Figure 3C and ref. 24). The gene discussed is NFKB1; the disease is vascular disorder.