CGA and gastric cancer: Fluorouracil is one of the most widely used first-line chemotherapeutic agents for GC and was preferred for our in vivo and in vitro experiments; since SGC7901ADR cells exhibit high resistance to Adriamycin and SGC7901VCR cells exhibit high resistance to paclitaxel (Supplemental Figure 1A), the 2 cell sublines after CGA knockout were treated with the respective drug related to their resistance when 2 agents were validated.