To further determine how SPHK1 upregulates PD‐L1 and how it affects tumor growth in vivo, we ectopically expressed (EE) SPHK1 in HeyA8 cells (Figure S2J, Supporting Information) and orthotopically injected those cells or control cells into the ovarian bursa of nude mice and monitored tumor growth. Here, SPHK1 is linked to neoplasm.