To further confirm that tumor‐associated EVs loaded with SPHK1 promote ovarian cancer progression, we performed a similar in vivo experiment by injecting SPHK1−/− ID8 cells treated with EVs isolated from parental ID8 cells or ID8 cells that ectopically expressed SPHK1 (Figure S4A, Supporting Information). This evidence concerns the gene SPHK1 and ovarian cancer.