Moreover, S1P signaling is also known to control immune cell trafficking.[5] Recently, S1P was found to regulate upstream signaling that affects the metabolic fitness of T cells in the tumor microenvironment (TME).[2] It was also shown that targeting S1P signaling improves tumor control in a dual fashion: by negatively controlling tumor growth and by increasing the antitumor activity of T cells.[6]. Here, MBTPS1 is linked to neoplasm.