In conclusion, we have shown that the number of immune cells in CD24‐high large B‐cell lymphoma was lower than in CD24‐low cases, suggesting that CD24 on lymphoma cells contributes to escape from immune surveillance as an immune checkpoint signal in DLBCL, leading us to speculate that CD24 will be a new target of immunotherapy of aggressive large B‐cell lymphoma. Here, CD24 is linked to diffuse large B-cell lymphoma.