In the multivariate Cox regression model, ki67 >10% (HR = 2.153, p = 0.048), HTB >50% (HR = 2.840, p = 0.003), and bone metastasis (HR = 2.911, p < 0.001) were independent risk factors affecting overall PFS (Table 3). This evidence concerns the gene MKI67 and bone metastasis.