Clinical studies have shown that CRS was mainly caused by the activated CAR‐T cell resulted in a significant increase in the secretion of pro‐inflammatory factors (e.g., IL‐6, IFN‐γ, and TNF‐α) by immune cells (T cells, B cells, natural killer cells, and monocytes/macrophages) that disrupt the balance between pro‐inflammatory and anti‐inflammatory responses.106. The gene discussed is IFNG; the disease is congenital rubella syndrome.