KMT2A and acute myeloid leukemia: Second, we discerned the lineage-independent effects of KMT2A translocation by overlapping the KTM2A-rearranged B-ALL cancer core transcriptome with genes differentially expressed in KMT2A-driven AML (relative to its normal cell correlate, monocyte progenitors (MOPs); case 10, Fig. 2a).