In our analysis, the only other PPARrelated gene within the IBD network, i.e., Pgc1a, and its role within the PPARα/γ axis suggests that the intricate network of forward feedback loops orchestrated by Pgc1a may be critical for achieving the critical balance between immunity and inflammation, which is a key outcome of the dual PPARα/γ agonists. This evidence concerns the gene PPARGC1A and inflammatory bowel disease.