We next generated an automated target report card for PPARA and PPARG. A high level of both PPARs, determined using a composite score for the abundance of both transcripts, was sufficient to distinguish healthy from IBD samples, not just in the test cohort that was used to build the IBD-map (ROC AUC of 0.74; Fig. 2b; see also Supplementary Fig. 2a–d), but also in four other independent cohorts with ROC AUC consistently above 0.88 (Fig. 2c). Here, PPARA is linked to inflammatory bowel disease.