CHKA and colorectal carcinoma: Although CKI can inhibit the progression of advanced CRC, enhance the efficacy of chemotherapeutic drugs, reduce the side effects of radiotherapy and chemotherapy, improve quality of life, improve prognosis6,9, and inhibit the proliferation, migration, and invasion of CRC cells in vitro12–14, its active ingredients, target genes, and molecular pathways by which it inhibits the development of CRC are still unclear.