It has been reported that a single systemic dose of AAV9-carrying MYBPC3 cDNA was able to restore MYBPC3 mRNA and protein levels and prevent the development of left ventricular hypertrophy (LVH) in MYBPC3-targeted knock-in mice with only 20% cMyBP-C protein28. Here, MYBPC3 is linked to left ventricular hypertrophy.