FHOD3 and familial dilated cardiomyopathy: The heterozygous FHOD3:p.T502fs variant observed in our patient with DCM was also found in a 100,000 Genomes Project patient with DCM, and three different heterozygous splice variants in FHOD3 were observed at the same site in patients in the replication cohorts, all with HCM: c.1646 + 1G > C in an Australian patient18, c.1646 + 1G > T in a 100,000 Genomes Project patient, and c.1646 + 1G > A in three 100,000 Genomes Project patients, suggesting a variant hotspot (Supplementary Fig. 1a; Supplementary Table 3).