PRMT7 and pulmonary emphysema: Inline, there was an increase in the percentage of monocyte-like macrophages in the bronchoalveolar lavage of COPD patients compared to healthy controls following scRNA-seq analysis (Supplementary Fig. 3d), with greater PRMT7 expression in the monocyte-like macrophages of COPD patients, particularly in current smokers with emphysema, compared to controls (Fig. 1n and Supplementary Fig. 3e).