ALOX5 and chronic obstructive pulmonary disease: Furthermore, we observed increased expression of ALOX5 in the CS-induced macrophage population following scRNA-seq of the lungs from CS-exposed mice (Supplementary Fig. 21e), likewise in monocyte-like macrophages from the bronchoalveolar lavage of COPD patients as determined by scRNA-seq (Fig. 1n).