Additionally, Prmt7+/− mice that were protected from emphysema development did not show increased expression of ACSL4 in alveolar epithelial cells following CS exposure (Fig. 5j, k), despite AT2 cells with impaired PRMT7 activity retaining the ability to upregulate ACSL4 (Supplementary Fig. 18g). Here, PRMT7 is linked to pulmonary emphysema.