Similarly, we confirmed an increase of PRMT7 in the lungs of a third COPD patient cohort, but not SETD4, GNMT, EZH2, or PNMT (Fig. 1e, f and Supplementary Fig. 1h), which was validated by increased inflammatory cytokines TNF (Fig. 1e), CXCL1 CCL2, IL8, and IL6 (Supplementary Fig. 1h). Here, CXCL1 is linked to chronic obstructive pulmonary disease.