EZH2 and chronic obstructive pulmonary disease: This was supported by determining increased PRMT7 expression in the lungs of a further independent cohort of COPD patients (GSE27597) compared to smoker controls (Fig. 1d) but not SETD4, GNMT, EZH2, or PNMT (Supplementary Fig. 1f), where PRMT7 expression positively correlated with lung tissue injury-induced airspace enlargement (Supplementary Fig. 1g).