SPP1 and lung cancer: The population of CS-induced macrophages that we discovered in this study shows high expression of Spp1, a COPD marker, and a co-expression of Gpnmb and Lgals3. Albeit, the dysregulation of PRMTs in human and experimental pulmonary diseases such as COPD, asthma, pulmonary hypertension, lung fibrosis, or lung cancer have been characterized, PRMT7 was not yet described.