SETD4 and chronic obstructive pulmonary disease: Similarly, we confirmed an increase of PRMT7 in the lungs of a third COPD patient cohort, but not SETD4, GNMT, EZH2, or PNMT (Fig. 1e, f and Supplementary Fig. 1h), which was validated by increased inflammatory cytokines TNF (Fig. 1e), CXCL1 CCL2, IL8, and IL6 (Supplementary Fig. 1h).