We have confirmed the hypermethylation and upregulation of numerous innate immune response genes including IFIH1, TNFAIP3, IFIT1 and IFIT2 following ALKBH5 knockdown during bacterial and viral infections as well as LPS treatment, indicating that these genes might be universally regulated by m6A during bacterial and viral infections. This evidence concerns the gene TNFAIP3 and viral infectious disease.