Both, unconditioned anxiety on the EPM and— in stark contrast to the hyperlocomotion phenotype of Gria1−/− mice [46]—novelty-induced locomotion in an open field were reduced in mice with hippocampal GluA1 knockout compared to their control group, but were unaffected by prefrontal GluA1 ablation (Fig. 1l and Supplementary Fig. 2). The gene discussed is GRIA1; the disease is Anxiety.