In summary, we found no evidence that GluA1 hypofunction in excitatory cells of the prefrontal cortex contributes to cognitive deficits related to schizophrenia in the battery of tests adopted here, whereas reduction of GluA1 in hippocampal excitatory cells may be responsible for at least some of the short-term memory deficits seen in this disorder. Here, GRIA1 is linked to schizophrenia.