Like mice with virally mediated GluA1 ablation in the hippocampus (Fig. 1l), Gria1ΔAmigo2—but not Gria1ΔGrik4—mice showed a marginally higher preference for entries into the open arm of the EPM, potentially indicating reduced anxiety (Fig. 2c; see Supplementary Tables 3 and 4 for statistical assessment of all behavioural tests conducted in the transgenic cohorts). The gene discussed is GRIA1; the disease is Anxiety.