Previous studies showed that the CMTM6 acts as an adaptor protein, binding to PD-L1 to mediate its endosomal recycling, thereby protecting PD-L1 from lysosomal degradation to maintain its quantity on the cell membrane.36 37 Interestingly, ATP11B and CMTM6 in pancreatic cancer were positively correlated (figure 6D), as revealed by the bioinformatic analysis using TCGA data sets. This evidence concerns the gene CD274 and familial pancreatic carcinoma.