Notably, the integrated bioinformatic analysis performed on multiple cancers showed that ATP11B expression was positively correlated with the expression of various immune-related modulators, including PD-L1, but negatively correlated with the activated CD8 +T cells (figure 5F, G, online supplemental figure S8A–D), suggesting the critical role of ATP11B in cancer immune resistance. This evidence concerns the gene CD274 and cancer.