In addition, the clinical significance of CMTM6 is further confirmed in head and neck squamous cell carcinoma, glioma, and gastric cancer.49–51 CMTM6 expression refines the prognostic value of PD-L1 in pancreatic cancer, and PD-L1high CMTM6high is associated with the worst prognosis, with a 27% 2-year overall survival.52 Although these results underline the therapeutic potential of CMTM6 as a promising target in combination with PD-1/PD-L1 blockade therapy, the targetability of CMTM6 is still largely unknown, indicating that the regulatory mechanism itself needs to be further investigated. Here, CD274 is linked to head and neck squamous cell carcinoma.