CD274 and familial pancreatic carcinoma: Interestingly, LTX-315 in combination with anti-PD-1 antibody was observed to induce a potent immune response and long-term immune memory protection in melanoma.30 Nevertheless, the therapeutic potential of LTX-315 and its feasibility in combination with PD-1/PD-L1 blockade for pancreatic cancer are largely unknown.