MTORC1 activation in diet-induced obesity (DIO) is considered central to the pathophysiology, contributing to fat deposition in the liver (Wang et al, 2015; Han & Wang, 2018), type-2 diabetes and insulin desensitization (Bar-Tana, 2020), lipogenesis (Zhang et al, 2009), and other abnormalities. The gene discussed is INS; the disease is type 2 diabetes mellitus.