NPPB and hydrops fetalis: Adlbrecht et al found that the Roche Cobas h 232 POC NT-proBNP measurement device had a 100% negative predictive value for HF-related hospitalisation, and better positive predictive value than any clinical sign or symptom when NT-proBNP was in the low range of 100–500pg/mL.15 In precisely these low concentrations, this study has shown that POC testing has the greatest precision.