NOTCH1 and aortic stenosis: Of the 89 patients with pathogenic and likely pathogenic NOTCH1 variants, 21 were reported in the context of syndromic disease including AOS (n=19), Shone complex (n=1) and 1 in a patient in whom congenital AS co-existed with myoclonic epilepsy and learning difficulties (online supplemental table 1; no: 9, 13, 32, 43, 47, 62).