METTL3 and neoplasm: Besides, high METTL3 expression in cancerous tissues was significant correlated with advanced T stage and poor tumor differentiation among HNSCC patients (Additional file 1: Table S1), and HNSCC patients with high expression of METTL3 had worse overall survival using our tissue microarray (TMA) (n = 100, p = 0.001; Fig. 1G, Additional file 3: Figure S2A).