Since m6A modification are regulated by its writers and erasers, and then we analyzed the expression of the main writers and erasers using the Cancer Genome Atlas (TCGA) data, and found the main m6A writers (METTL3, METTL14, WTAP, RBM15) and erasers (FTO, ALKBH5) were significantly increased in HNSCC tissues than normal tissues (Fig. 1B, Additional file 2: Figure S1A). The gene discussed is RBM15; the disease is head and neck squamous cell carcinoma.