METTL3 and head and neck squamous cell carcinoma: To determine the roles of METTL3 in HNSCC metastasis, we also performed migration and invasion assays, and the results revealed that knockdown of METTL3 suppressed the migration and invasion of SAS and FaDu cells, however, overexpression of METTL3 dramatically promoted these effects in Hep2 cells (Fig. 2G–I).