To determine the efficacy of osimertinib plus bevacizumab in LM in EGFR-mutant NSCLC, we constructed a model of LM with lateral ventricle injection (Fig. 2A), and the lung cancer LM xenograft model was confirmed by IVIS imaging, MRI, and H&E (Fig. 2B, C and E). Here, EGFR is linked to lung carcinoma.