TP53 and cervical intraepithelial neoplasia: Studies found that HIV protease inhibitor lopinavir inhibited the ability of HPV16 E6 in degrading p53 expression in vitro [36], lopinavir increased expression of antiviral protein in HPV positive cervical carcinoma cells [37], and ritonavir or saquinavir inhibited cervical intraepithelial neoplasia progression in either HIV-infected or uninfected women [38].