In diffusely infiltrating gliomas, the mutational status of isocitrate dehydrogenase (IDH) and other molecular features determines biological behavior and defines the diagnostic category of IDH-mutant (IDH-mt) astrocytoma and 1p/19q codeletion oligodendroglioma (Louis et al. 2016). This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).