Among the TME and immune signatures, astrocytoma indicated overall increased infiltration abundance, which included inflamed immune checkpoints, human leukocyte antigen (HLA) signatures, myeloid-derived suppressor cells (MDSCs), and oligodendroglioma presented inflamed dendritic cells (DCs) and CD4 + and CD8 + T cells, similar to previous findings. The gene discussed is CD8A; the disease is astrocytoma (excluding glioblastoma).