NPPA and hydrops fetalis: Moreover, the protein expression levels of the LVH markers ANP and BNP were notably elevated in the HF hearts compared to that in the sham hearts (P < 0.05; Figure 4e–g), and MCC950 administration markedly reversed HF-induced LVH, as indicated by significantly decreased ANP and BNP protein expression levels (P < 0.05; Figure 4e–g).