For example, tissue transglutaminase-1 (TGM1) can promote the stemness and chemotherapy resistance of GC cells by activating the Wnt/β-catenin pathway [14]; DVL3 participates in activating the Wnt/β-catenin pathway to enhance the CSC stemness of GC cells [40,41]. The gene discussed is DVL3; the disease is gastric cancer.