However, we should also take notice of AIM2 and NLRC4 because their transcript expression was much higher upregulated by spike protein transfection in AT-II and Beas-2B cells (Figures 2A–2D) and induced by pseudovirus infection in hACE2 transgenic mice (Figure 4E), and previous studies have shown that autoinflammation with pyroptosis in a COVID-19 patien was because of mutations in NLRC4 (Duncan-Lowey et al., 2021) and COVID-19 infecting blood monocytes to activate the AIM2 inflammasome (Junqueira et al., 2021). Here, NLRC4 is linked to COVID-19.